Author Archives: Sean P. Kane

CRASH 2 Brief Summary – Tranexamic acid in trauma patients

ICU Trials by ClinCalc

Ready to improve your ICU knowledge? Check out ICU Trials for iPhone and Android, a pocket reference for 70+ landmark critical care trials, including CRASH 2.

Summary of the CRASH 2 Trial

Tranexamic acid reduced all-cause mortality in a broad population of trauma patients without an increase in vascular occlusion complications.

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Learn the Top 200 Drugs with FlashRX on iPhone and Android

FlashRX by ClinCalc - adaptive-learning flashcards and quizzes for the top 200 drugs

There’s nothing that smells sweeter than a freshly based mobile app for medical education.  Our newest app, FlashRX by ClinCalc, is no exception!

As a professor, I commonly see frustrated students with complicated drug cards that provide excessive, non-prioritized information.  Instead of these complicated drug cards, FlashRX’s drug database focuses on simple, usable information to develop a core knowledge base. This emphasis on practical knowledge will improve learning and comprehension of the top 200 drugs.

Click here to read more about FlashRX and download it for your iPhone or Android mobile device.

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Fresenius Kabi: It’s Time to Pull the Plug on Voluven (hydroxyethyl starch 130/0.4)

Voluven (hydroxyethyl starch 130/0.4) was heralded to the hospital community as a cheaper alternative to albumin, but safer than previous hydroxyethyl starch (HES) products that were shown to cause bleeding and renal failure.

Although Voluven is likely “safer” than older HES products, it still is NOT safer than traditional volume repletion with normal saline or albumin.  It was a good run, Voluven, but it’s time to pull the plug.

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What makes something a “landmark” critical care trial?

I receive quite a bit of feedback regarding one of my more popular mobile applications, ICU Trials by ClinCalc.  Often, these emails involve a request to add a particular “landmark” trial with the next application update.  With 10-20 recent requests for new trial additions, I’ve been forced to re-evaluate my criteria for what constitutes a seminal paper in the area of critical care medicine.

Although there isn’t an official scoring system or absolute list of must-have criteria, I’ve developed a simple list of ten important factors that help differentiate important trials from paramount, landmark gems in evidence-based medicine.

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